Football watch parties are synonymous with eating fatty foods and drinking alcohol. Have you ever wondered what all of that eating and drinking does to your body?
Researchers from the University of Missouri School of Medicine simulated a tailgating situation with a small group of overweight but healthy men and examined the impact of the eating and drinking on their livers using blood tests and a liver scan. They discovered remarkably differing responses in the subjects.
“Surprisingly, we found that in overweight men, after an afternoon of eating and drinking, how their bodies reacted to food and drink was not uniform,” said Elizabeth Parks, PhD, professor of nutrition and exercise physiology. “In some people, the body responded in a unique way to take the stress off the liver. These findings reveal that both genetics and lifestyle can work together to protect us from overconsumption of nutrients.”
Parks studied 18 men who were given alcoholic drinks to elevate breath alcohol levels for five hours while they were provided hamburgers, chips and cupcakes. The men ate an average of 5,087 calories, which increased their blood levels of glucose, insulin and fats called triglycerides. Despite all subjects maintaining breath alcohol levels of 0.08 to 0.10, nine men showed increased fat in the liver, five men showed a decrease in liver fat and one man experienced no change at all. Unexpectedly, those with an elevated amount of liver fat drank 90% less alcohol and tended to eat more carbohydrates compared to the other subjects.
“A potential explanation of these findings is that high carbohydrate consumption may have a greater impact on liver fat than alcohol in some people,” Parks said. “Given the high prevalence of overconsumption of food and alcohol in the U.S., further studies are needed in a larger population. Our goal is to understand differences between people in how they respond to excess food and alcohol. It may be that limiting meal carbohydrates may protect the liver.”
In addition to Parks, the study authors include former and current trainees, Majid Syed-Abdul, Miriam Jacome-Sosa, Nathan Winn, Qiong Hu and Justine Mucinski; research assistants Nhan Lee and Jennifer Anderson; and fellow MU faculty collaborators Ayman Gaballah, MD, associate professor of radiology; Camila Manrique- Acevedo, MD, associate professor of medicine; Guido Lastra Gonzalez, MD, associate professor of medicine; Alhareth Al Juboori, MD, clinical instructor of medicine; and Bruce Bartholow, PhD, Frederick A. Middlebush Professor of Psychology.
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